Cardiovascular disease is the commonest cause of death in patients treated with end stage renal disease (ESRD). Left ventricular hypertophy (LVH) may occur frequently in patients with ESRD. Some factors such as increased preload, hypertension
hyperparathyroidism. Anemia, hemodialysis duration could be associated with LVH in ESRD. To determine the most important risk factors that independently relate to LVH among them 24 ESRD patients on hemodialysis, 13 normal subjects. 11 essential
hypertension patients had echocardiography and clinical review.
The LVMI of ESRD patients was significantly higher than that of control group (168.04g/m2 vs 123.46g/m2, P<0.05) and higher than that of hypertensive group (168.04 vs 147.15 g/m2). Among factors that may independently relate to LVH in ESRD
patients,
only systolic and diastolic blood pressure were correlate significantly to LVMI (r=0.6, r=0.59, P<0.05 respectively). If ESRD patients were devided into 4 subgroups dependent upon systolic and diastolic pressure, the LVMI of each
subgroup(systolic
blood
pressure>150 mmHg or diastolic blood pressure>90 mmHg) was significantly higher than that of each subgroup (systolic pressure<150 mmHg or diastolic pressure<90 mmHg) (P<0.05). Using multiple regression, systolic and diastolic blood pressure were
most
important factors which independently related to LVH, followed by anemia. Level of parathyroid hormone, the amount of ultrafiltration, hemodialysis duration were not related to LVH. It is concluded that the most important factors associated with
LVH in
ESRD are hypertension, anemia.
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